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Dedicated to the Advancement of Oral Care
Nuvora was formed in 2007 by a team of experienced drug delivery experts to develop and commercialize oral care products based on the patented SuRe™ (Sustained Release) drug delivery technology.
SuRe TM is Superior to Conventional Oral Care Technologies
Dentists and hygienists have always known that optimal oral care is dependent on the length of time ingredients stay active in the mouth. The longer an ingredient is active in the mouth the better it is at fighting bacteria, plaque, bad breath or gum disease. But, conventional oral care products, such as toothpaste or mouthwashes, are only active for a few minutes before they are either expelled or washed away by saliva. As a result, harmful plaque bacteria or bad breath causing bacteria can grow again soon after these products are used. This is where SuRe is different. The sustained release characteristics of the SuRe technology allows for extended delivery of oral care ingredients.
Transforming Oral Hygiene
Following months of extensive tests at leading Universities, our researchers developed a small, soft, pliable lozenge that rests comfortably in the mouth where it releases active ingredients, not for seconds or a few minutes, but for hours at a time. This new method of delivering oral care ingredients has shown to be more efficient and effective than conventional technologies.
Research confirmes that oral care lozenges:
- Fight specific conditions like dry mouth or halitosis
- Kill more germs than the leading mouth rinse
- Inhibit bacteria growth
- Maintains healthy teeth and gums
- Neutralize acidic pH
- Provide long lasting fresh breath
WHY OUR TECHNOLOGY IS BETTER
About SuRe Technology
Nuvora has developed the patented Sustained Release (SuRe®) Technology for making lozenges for release of ingredients into the oral cavity. Conventional oral care systems (paste, rinse, lozenges, etc.) deliver active ingredients for a short period of time, ranging from 30 seconds for rinse products to approximately 2 minutes for paste or 5-10 minutes for lozenges. These short residence times in the mouth are insufficient for adequate treatment of oral problems.
Using the Nuvora technology, 2 products have been developed: Salese for dry mouth, and Dentiva for oral care.
Technology
Nuvora has developed the patented Sustained Release (SuRe® Technology) lozenge that can be formulated to last 30 minutes to an hour or longer vs 5 -10 minutes for conventional lozenges, allowing sustained and consistent delivery of active ingredients in the oral cavity. Specifically, this technology is a matrix constructed of a cellulose polymer, essential oils and active ingredients. All base ingredients are registered food products and are GRAS (Generally Recognized As Safe).
The resulting product takes the form of a small, soft lozenge which holds the active ingredients uniformly distributed throughout the lozenge. The dissolution of the lozenge works via a process of slow erosion to delivers an even and continuous stream of active ingredients for the life of lozenge. Thus, a lozenge formulated to last for an hour will continuously release a constant amount of active ingredients for that period of time while maintaining the same pleasant flavor for the entire period.
The Advantages of the SuRe® Technology are as Follows:
- Continuous bathing of oral tissues (e.g., gums) with active ingredients for an extended time. If an ingredient is in the mouth for a short period of time and the purpose of the ingredients is for treating the oral tissues, then there is insufficient time for the ingredients to do their job.
- Consistent release of ingredients. SuRe® technology delivers a gradual, uniform stream of active ingredients which remains constant throughout use of the product. Thus, the lozenge, if designed to last 30 minutes, will taste exactly the same at 30 minutes as it did when the lozenge was put in the mouth.
- Continuous and consistent release of ingredients results in greater efficacy. One gives the right amount of ingredients for the correct amount of time. Thus, there is no need to give a large amount of any ingredient in the hope that some of it will work before being swallowed. Most other products (medicated candies, etc.) release a large amount of ingredients into the mouth, most of which is ingested and does not get into the oral tissues due to short residence time in the mouth.
- Multiple ingredients can be incorporated into the lozenge. This results in the ability to handle multiple oral hygiene problems simultaneously.
- For Dentiva, this means the ability to lower bacterial levels, capture and eliminate bad breath odors, neutralize cavity causing acids, and remineralize the teeth using ingredients specific for each task. The result in a multi-purpose oral hygiene product.
- For Salese, Nuvora added an ingredient to create the moist mouth feel for relief of dry mouth and also added the ingredients in Dentiva for oral hygiene (reduce bacterial levels, eliminate breath odors, neutralize acids).
Demonstrated key technology benefits
| Efficacy | Sustained release of actives achieves higher bacteria kill rate when compared to the leading anti-bacterial rinse. |
| Substantivity | Post treatment SuRe technology maintained higher bacteria kill rate while the rinse treated leg returned to pre treatment levels. |
| Dosage | SuRe technology achieved higher bacteria kill rate with a substantially lower dosage of actives:
0.5g SuRe lozenge (essential oils, xylitol) |
LEADERSHIP AT NUVORA
Jerry Gin – Founder
Jerry is a serial entrepreneur who brings 40 years of experience in the health care, pharmaceutical and biotech field to Nuvora. He is a co-founder of Nuvora and also oversees the development of new applications for Nuvora’s technology platform. Prior to starting Nuvora, Jerry was co-founder/CEO of Oculex Pharmaceuticals and co-founder/Executive VP of ChemTrak as well as a director at Syva/Syntex Pharmaceuticals and Dow Chemical.
Ben Ross – Founder
Ben brings 30 years of operations, manufacturing and product development experience to Nuvora. He is co-founder of Nuvora and oversees the company’s product development and manufacturing operations. Before starting Nuvora, Ben was VP of Operations at Oculex Pharmaceuticals. Prior to Oculex, Ben held positions overseeing operations and manufacturing at Monoclonal Antibodies, Biotrack, Abaxis and Syva/Syntex Pharmaceuticals.
Bolko Stolberg – Founding Partner
Bolko brings 25 years of business management experience in consumer goods and health care fields to Nuvora. Since joining the company, Bolko has overseen all strategic and commercialization efforts for Nuvora’s product line. Prior to joining Nuvora, Bolko was VP of Marketing & Business Strategy at Avicena Group and has held various international senior leadership positions at Gillette and Procter & Gamble.
SCIENTIFIC ADVISORS
Dr. John Featherstone, MS.c., Ph.D.
Dr. Featherstone is a Professor and the Dean at the University of California San Francisco (UCSF) School of Dentistry and is the current Chair of the Department of Preventive and Restorative Dental Sciences.
Dr. Peter Jacobsen, Ph.D.
Dr. Jacobsen is an Adjunct Professor in the Arthur Dugoni School of Dentistry, University of the Pacific and is Vice-Chairman of the ADA Council on Scientific Affairs.
Dr. Mitchell Day, D.D.S
Dr. Mitchell Day served as oral surgeon for the Veterans Affairs Hospital, Palo Alto. He also served as Professor in the Arthur Dugoni School of Dentistry, University of Pacific and as Director of Oral & Maxillofacial Clinics, University of Minnesota.